Examples of research projects in West Sweden
Autologous chondrocyte transplantation (Prof. Anders Lindahl)
Aims to regenerate large area full depth chondral defects in the articular cartilage. The pioneering work in cartilage tissue engineering was performed in Gothenburg more than 20 years ago and the technology referred to as ACI (Autologous chondrocyte implantation) today is spread worldwide with more than 30000 patients treated.
Autologous stem cell therapy to treat disc degeneration (Prof. Helena Brisby)
Chronic back pain can be caused by degeneration of the intervertebral discs. The patient’s own mesenchymal stem cells are harvested and expanded in cell culture. The mesenchymal stem cells are then injected into the degenerated discs, where they are expected to integrate and to produce proteins that contribute to regeneration of the intervertebral discs.
Uterus transplantation (Prof. Mats Brännström)
The uterus transplantation project at the University of Gothenburg started in 1999. More than 40 scientific articles on uterus transplantation were published before the first clinical trial was launched in 2013. The world´s first baby after uterus transplantation was born within this trial in 2014 and this has been followed by several more births.
3D bioprinting of skin and cartilage (Prof. Paul Gatenholm)
With the 3D Bioprinting technology it is today possible to use human cells to print functional human tissue. In the future the tissue can replace damaged tissue. The tissue models can be used to test new products and thus improve quality of life, and in transplantation.
SP Technical Research Institute of Sweden (Benny Lyvén, Joakim Håkansson, Jim Lund)
Collaborating with industry on tissue engineered veins and arteries based on de-recellularization technology, SP is also coordinating a national project aiming at the next generation test systems based on technology from regenerative medicine. Another example is the Broken hearts project that aims to develop a test system for ischemia reperfusion models and other cardiac-specific disease models.